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Mixed Tocopherols Dietary SupplementFoundationalHeart/VesselsUltimate E contains a mixture of all tocopherols and utilizes molecular distillation to remove allergenic soy residues. Vitamin E is a vital antioxidant and has been shown to benefit the cardiovascular system.Thorne's Ultimate-E contains mixed tocopherols and provides vital antioxidant activity in fat-soluble tissues. Numerous clinical studies have shown vitamin E is beneficial to the cardiovascular system. Ultimate-E with its naturally occurring ratio of tocopherols is an efficient way to supplement vitamin E – without the addition of soy oil as a filler. And recent studies looking at mixed tocopherols indicate they have a stronger inhibitory effect on lipid peroxidation than alpha-tocopherol alone indicating a more potent antioxidant effect. Thorne's vitamin E ingredient is extracted from a mixture of vegetable oils including soy oil. However any potentially allergenic soy residue is removed during the distillation process and Ultimate-E is not diluted with soy oil.Tocopherols provide protection from free radicals and other by-products of oxygenation including lipid peroxides and singlet oxygen radicals. Gamma-tocopherol inhibits the enzyme cyclooxygenase whereas alpha-tocopherol does not appear to have a significant effect on this enzyme. Human studies comparing diets supplemented with gamma- and alpha-tocopherols to diets supplemented primarily with only alpha-tocopherol found more DNA protection in the mixed-tocopherol group than the alpha-tocopherol group. Because the tocopherols in Ultimate-E come from a natural source the tocopherol profile can vary slightly from batch to batch although extra alpha-tocopherol is added to each batch that is manufactured to standardize the amount of this important tocopherol to 500 IU per gel cap.